炎症标志物与心房颤动相关卒中关系的研究进展

Research progress on the relationship between inflammatory markers and stroke in patients with atrial fibrillationn

急性缺血性脑卒中具有发病率高、致残率高、复发率高的特点,给家庭和社会带来了沉重的负担。与非心房颤动相关卒中相比,心房颤动相关卒中的症状更重,致残率、病死率更高,容易复发。目前关于心房颤动引起卒中的机制的假设包括内皮损伤、高凝、炎症、心房重塑、左心耳形态等,其中炎症标志物在心房颤动发生及发展为缺血性卒中的过程中起着重要作用。因此,关于炎症因子与心房颤动相关卒中的研究对于心房颤动患者的卒中预防及心房颤动相关卒中的临床用药指导有着重要意义。本文主要综述炎症因子与心房颤动相关卒中的联系。

Acute ischemic stroke is characterized by high incidence rate,high disability rate and high recurrence rate,resulting in a high burden on the family and society.Compared with non atrial fibrillation(AF)related stroke,AF related stroke has more severe symptoms,higher disability rate,higher mortality,and easy recurrence.Due to the oversimplification of the traditional association mechanism between AF and stroke,many hypotheses have emerged regarding the mechanism of AF causing stroke,such as endothelial injury,hypercoagulable state,inflammation,atrial remodeling,and left atrial morphology.Inflammatory markers are important factors in the development of atrial fibrillation and stroke.Therefore,research on the correlation between inflammatory factors and AF related stroke is of great significance for stroke prevention in AF patients and clinical medication guidance for AF related stroke.This article mainly reviews the relationship between inflammatory factors and AF related stroke.