放射性核素探针在嵌合抗原受体T细胞治疗显像中的应用

Application of radionuclide probes in chimeric antigen receptor T cell therapy imaging

嵌合抗原受体T细胞(CAR-T)疗法是一种新型的过继细胞疗法,近几年在肿瘤治疗领域中受到广泛关注,尤其是在血液系统肿瘤(如急性淋巴细胞白血病和弥漫性大B细胞淋巴瘤)的治疗中发挥着关键作用。但该疗法受复杂的肿瘤微环境、靶点特异性等因素影响而在实体瘤中的应用较为有限。基于放射性核素的分子成像,通过对T细胞体内状态进行示踪,可更好地实现CAR-T的可视化与治疗监测,并反映CAR-T的功能信息与免疫状态,对CAR-T疗法疗效的预测与安全性评价具有重要的指导意义。笔者将系统介绍基于放射性核素的分子成像策略在CAR-T疗法应用中的最新进展。

Chimeric antigen receptor T cell(CAR-T)therapy is a novel adoptive cell therapy,and has received extensive attention in the field of tumor therapy in recent years,especially in the treatment of hematological tumors,such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma.However,its application in solid tumors is limited because of the complex tumor microenvironment and target specificity.Molecular imaging based on radionuclides can better realize the visualization and therapeutic monitoring of CAR-T cells,and reflect the functional information and immune status of CAR-T cells,which has important guiding significance for the prediction and safety evaluation of CAR-T cells.This review will systematically introduce the latest advances in the application of radionuclide based molecular imaging strategies in CAR-T therapy.