摘要
二氢杨梅素(dihydromyricetin,DHM)是广泛存在于葡萄科蛇葡萄属植物中的一种二氢黄酮类化合物,具有抗炎、抗菌、抗肿瘤、抗氧化、调血糖、降血脂、肝保护等多种药理作用。近年的研究表明,DHM具有很好的神经保护作用,对多种神经系统病变包括阿尔茨海默病、抑郁症、帕金森综合征、脑卒中等均能起到一定的药理作用。该文针对近十年国内外对DHM的神经保护作用的相关研究进行综述,旨在为DHM的神经保护作用研究提供思路。
Dihydromyricetin is a dihydroflavone compound which widely exists in ampelopsis of grapevine family.It has many pharmacological effects,such as anti-inflammatory,antibacterial,anti-tumor,antioxidant,regulating blood glucose,reducing blood lipid,liver protection and so on.In recent years,it has been found that dihydromyricetin has a good neuroprotective effect and can play a certain pharmacological role in a variety of neurological diseases,including Alzheimer′s disease,depression,Parkinson′s disease and stroke.The purpose of this paper is to review the research on the neuroprotective effect of dihydromyricetin in the past decade.
作者
龙俊鹏
孙洋
刘莎莎
姚娇
阳松威
杨岩涛
裴刚
艾启迪
陈乃宏
LONG Jun-peng;SUN Yang;LIU Sha-sha;YAO Jiao;YANG Song-wei;YANG Yan-tao;PEI Gang;AI Qi-di;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Xiangtan Central Hospital,Xiangtan,Hunan 411199,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第8期1422-1425,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82174271)
湖南省自然科学基金项目(No 2021JJ30512)
湖南乾坤生物科技有限公司莓茶资源综合利用科技专项计划(No 212010)
湖南省科技厅优秀青年项目(No 21B0354)
长沙市自然科学基金(No kq2202269)
湖南中医药大学生物工程重点学科([2018]No 3)。
关键词
二氢杨梅素
神经保护
研究进展
阿尔茨海默病
脑卒中
dihydromyricetin
neuroprotection
research progress
Alzheimer′s disease
cerebral ischemia
