地尔硫卓联合美托洛尔对不稳定型心绞痛患者的影响

Effect of Diltiazem Combined with Metoprolol on Patients with Unstable Angina

目的:研究地尔硫卓联合美托洛尔对不稳定型心绞痛患者的影响。方法:选取2022年1—8月深圳市人民医院龙华分院收治的146例不稳定型心绞痛患者为研究对象。根据随机数表法将其分为观察组及对照组,各73例。两组均给予常规治疗,对照组在此基础上予以酒石酸美托洛尔片,观察组则在对照组基础上增加盐酸地尔硫卓片。比较两组临床疗效,治疗前后心功能指标、运动耐力相关指标及不良反应。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组左室舒张末期内径(LVEDD)及左室收缩末期内径(LVESD)均短于对照组,左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组6分钟步行试验(6MWT)距离长于对照组,改良英国医学研究委员会呼吸困难量表(mMRC问卷)评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地尔硫卓联合美托洛尔治疗不稳定型心绞痛患者的效果较好,还可提升其运动耐力,改善心功能指标,安全性较好。

Objective:To study the effect of Diltiazem combined with Metoprolol on patients with unstable angina.Method:A total of 146 patients with unstable angina treated in Longhua Branch of Shenzhen People's Hospital from January to August 2022 were selected as study objects.They were divided into observation group and control group according to random number table method,with 73 cases in each group.Both groups were given conventional treatment,the control group was given Metoprolol Tartrate Tablets on this basis,the observation group was given Diltiazem Hydrochloride Tablets on the basis of the control group.The clinical efficacy,cardiac function indexes,exercise endurance related indexes before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)in the observation group were shorter than those in control group,and left ventricular ejection fraction(LVEF)was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,the 6 min walking test(6MWT)distance of the observation group was longer than that of the control group,and the score of the modified British Medical Research Council dyspnea(mMRC questionnaire)was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Diltiazem combined with Metoprolol in the treatment of patients with unstable angina has a good effect,can also improve their exercise endurance,improve cardiac function indexes,and has good safety.