柴胡陷胸汤合蒿芩清胆汤加减治疗癌症放疗后胆汁反流性胃炎的临床效果

Clinical Effect of Chaihu Xianxiong Decoction and Haoqin Qingdan Decoction Modified in the Treatment of Bile Reflux Gastritis after Cancer Radiotherapy

目的:分析柴胡陷胸汤合蒿芩清胆汤加减治疗癌症放疗后胆汁反流性胃炎(bile reflux gastritis,BRG)的临床效果。方法:选取2019年1月—2020年12月龙口市中医医院收治的120例癌症放疗后BRG患者。根据随机数字法将其分为对照组和中医组,各60例。对照组给予常规用药方案治疗,中医组在对照组基础上给予柴胡陷胸汤合蒿芩清胆汤加减治疗。比较两组临床疗效,症状消除时间,治疗前后炎症因子及不良反应。结果:中医组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。中医组腹痛腹胀、反酸、嗳气、烧心症状消除时间均显著早于对照组,差异有统计学意义(P<0.05)。治疗后,中医组白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平均显著低于对照组,差异有统计学意义(P<0.05)。中医组不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:柴胡陷胸汤合蒿芩清胆汤加减治疗癌症放疗后BRG患者可快速消除疾病症状和炎症反应,取得理想疗效,且减少不良反应。

Objective:To analyze the clinical effect of Chaihu Xianxiong Decoction and Haoqin Qingdan Decoction Modified in the treatment of bile reflux gastritis(BRG)after cancer radiotherapy.Method:A total of 120 patients with BRG after cancer radiotherapy treated in Longkou Traditional Chinese Medicine Hospital from January 2019 to December 2020 were selected.According to random number method,they were divided into control group and traditional Chinese medicine group,60 cases in each group.The control group was treated with conventional medication plan,and the traditional Chinese medicine group was treated with Chaihu Xianxiong Decoction and Haoqin Qingdan Decoction Modified on the basis of the control group.The clinical efficacy,symptom elimination time,inflammatory factors before and after treatment and adverse reactions were compared between the two groups.Result:The treatment total effective rate of traditional Chinese medicine group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The elimination time of abdominal pain and distension,acid reflux,belching and heartburn symptoms in the traditional Chinese medicine group were significantly earlier than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)in the traditional Chinese medicine group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in traditional Chinese medicine group was significantly lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of BRG patients after cancer radiotherapy,Chaihu Xianxiong Decoction and Haoqin Qingdan Decoction Modified can quickly eliminate disease symptoms and inflammatory reactions,achieve ideal efficacy and reduce adverse reactions.