内源性大麻素系统及其在癌症中的作用机制研究进展

Research advances in anti-tumor effects of endocannabinoid system

目的讨论内源性大麻素系统(endocannabinoid system,ECS)的构成及其发挥抗癌作用的分子机制。方法通过查阅总结近年来相关文献,综述了ECS的作用机制,及作用于ECS的药物研究现状。结果ECS参与调节人类生理、行为、免疫和代谢等功能的各个方面,可通过多种途径发挥抗癌作用,具有临床研究及应用价值。结论ECS可调节细胞生长、代谢、分化、迁移、血管生成、诱导凋亡等通路,是极具价值的癌症治疗靶标,综述内容可为今后ECS在癌症治疗中的进一步研究提供参考。

Objective To discuss the composition of endocannabinoid system(ECS)and the molecular mechanism of its anticancer effects.Methods By reviewing and summarizing the relevant literature in recent years,the mechanism of ECS and the research status of drugs acting on ECS were reviewed.Results ECS are involved in the regulation of various aspects of human physiology,behavior,immunity and metabolism,and can exert anti-cancer effects through a variety of ways,which has clinical research and application value.Conclusion ECS can regulate cell growth,metabolism,differentiation,migration,angiogenesis,apoptosis and other pathways,which is a valuable therapeutic target for cancer.This review can provide reference for further research of ECS in cancer therapy.