鞘磷脂酶在消化道恶性肿瘤中的研究进展

Research progress of sphingomyelinase in gastrointestinal cancers

鞘磷脂酶(SMPD)是一种可以将鞘磷脂水解为神经酰胺和磷酸胆碱的水解酶,在鞘磷脂代谢中起主要作用。相关研究显示,SMPD家族在多种类型肿瘤中异常表达,并且在肿瘤发生、发展、耐药等方面发挥重要调控作用。因此SMPD有望成为肿瘤诊断和预后预测的标志物及治疗靶点,具有重要的临床转化价值。本文集中阐述了SMPD全家族分子的结构和功能特点,并综述SMPD在消化道恶性肿瘤中的作用及其机制研究进展,从而为消化道恶性肿瘤的靶向治疗及患者预后评估提供新的研究思路和策略。

SMPD protein family is a kind of hydrolase that plays a major role in sphingomyelin metabolism.At present,relative researches have found that the members of SMPD are abnormally expressed in different types of tumors,and play a key role in the occurrence,development and drug resistance of cancer.Thus,SMPD family is expected to be a potential predictor for tumor diagnosis,prognosis and treatment.Therefore,this review summarizes the structure and function of SMPD gene and protein,and elucidates the research finding of SMPD in gastrointestinal cancers,which provides new ways and strategies into precision medicine and prognosis evaluation.