1990—2019年中国脑和中枢神经系统肿瘤疾病负担

Disease burden of tumors of brain and central nervous system in China from 1990 to 2019

目的了解1990—2019年中国脑和中枢神经系统肿瘤(以下简称"脑瘤")发病、死亡和疾病负担情况,为制定有效的脑瘤防治策略提供科学依据。方法利用2019年全球疾病负担数据库,分析1990—2019年中国脑瘤总人群和不同年龄组间发病率、死亡率和伤残调整寿命年(disability adjusted life years,DALY)率。结果2019年中国脑瘤发病率和死亡率分别为6.66/10万和4.47/10万,比1990年分别升高了72.09%和39.25%;2019年中国脑瘤DALY率为144.37/10万,较1990年降低了3.43%。2019年发病率、死亡率和DALY率最高的年龄组均为≥55岁年龄组,分别为13.31/10万、11.84/10万和136.06/10万。1990—2019年中国脑瘤标化发病率呈升高趋势,平均年度变化百分比(AAPC)为0.82%(95%CI:0.61%~1.12%,P<0.001),标化死亡率和标化DALY率呈降低趋势,AAPC分别为-0.32%(95%CI:-0.43%~0.24%,P<0.001)和-1.37%(95%CI:-1.53%~-1.17%,P<0.001)。2019年中国脑瘤标化发病率和标化DALY率高于全球平均水平。结论中国脑瘤死亡率和DALY率近年来呈降低趋势。但由于中国人口基数大,在全球范围内脑瘤负担占比仍然较大,应采取积极的预防措施以减轻脑瘤的疾病负担。

Objective To understand the incidence,death and burden of tumors of brain and central nervous system(brain tumors)in China from 1990 to 2019,so as to provide a scientific basis for the development of effective prevention and treatment strategies of brain tumors.Methods Global Disease Burden Database 2019 was used to analyze the incidence rate,mortality rate and disability adjusted life years(DALY)rate of brain tumors in China from 1990 to 2019 among the general population and different age groups.Results In 2019,the incidence and mortality rates of brain tumors in China were 6.66/100000 and 4.47/100000,respectively,which increased by 72.09%and 39.25%compared with those in 1990.In 2019,DALY rate of brain tumors in China was 144.37/100000,which decreased by 3.43%compared with that in 1990.In 2019,the highest incidence,mortality and DALY rates were 13.31/100000,11.84/100000 and 136.06/100000,respectively,in the age group≥55 years old.From 1990 to 2019,age-standardized incidence rate of brain tumors in China showed an upward trend,with the average annual percent change(AAPC)of 0.82%(95%CI:0.61%-1.12%,P<0.001).And age-standardized mortality rate and age-standardized DALY rate showed a downward trend,with AAPC of-0.32%(95%CI:-0.43%-0.24%,P<0.001)and-1.37%(95%CI:-1.53%--1.17%,P<0.001),respectively.In 2019,age-standardized incidence rate and age-standardized DALY rate of brain tumors in China were higher than the global averages.Conclusions Mortality rate and DALY rate of brain tumors in China have decreased in recent years.However,the burden of brain tumors in China is still heavy due to the huge population.Active preventive measures should be taken to reduce the burden of brain tumors.