隐匿性乙型肝炎病毒感染研究进展

Advances in occult hepatitis B virus infection

隐匿性HBV感染属于HBV感染的一种特殊形式,指患者血清中HBsAg无法被检测到,但可以在患者血清和(或)肝脏组织中可检测出HBV DNA。隐匿性HBV感染是一种临床诊断较为困难的HBV相关肝病,可缓慢进展,也可导致HBV再激活,甚至肝硬化、肝细胞癌的发生。为防止隐匿性HBV感染者发生临床严重结局,应尽早诊断、加强监测、积极控制相关危险因素。

Occult hepatitis B virus infection(OBI)is a special form of HBV infection,which means that serum HBsAg cannot be detected,but HBV DNA can be detected in the serum and/or liver tissue.OBI is a kind of HBV related liver disease that is difficult to diagnose clinically.It can progress slowly,and lead to HBV reactivation,liver cirrhosis and hepatocellular carcinoma.Early diagnosis,strengthened monitoring,and active control of relevant risk factors should be carried out to prevent the occurrence of severe clinical outcomes in patients with OBI.