性激素结合球蛋白参与糖尿病发生发展的研究进展

Research progress on sex hormone-binding globulin involved in the occurrence and development of diabetes mellitus

性激素结合球蛋白(SHBG)与糖代谢异常发生显著相关。低血清SHBG水平是胰岛素抵抗以及糖尿病发生的一个危险因子。SHBG与2型糖尿病发病风险呈负相关,在预测胰岛素抵抗发展的同时也对其起重要的调节作用。SHBG的基因型被发现糖尿病的发生密切相关,脂肪肝及DNA甲基化也是介导SHBG与2型糖尿病关系的重要因素。而SHBG水平的改变与胰岛素抵抗的联系可能是通过影响肝细胞核因子4a及调节葡萄糖转运蛋白实现的。

Sex hormone-binding globulin(SHBG)is significantly associated with abnormal glucose metabolism.Low SHBG level is a risk factor for insulin resistance and the occurence of diabetes mellitus.SHBG is negatively correlated with the risk of type 2 diabetes mellitus and plays an important role in regulating insulin resistance while predicting its development.The genotype of SHBG has been found to be closely related to the occurrence of diabetes mellitus.Fatty liver and DNA methylation are also important factors mediating the relationship between SHBG and type 2 diabetes mellitus.The change in SHBG level may be related to insulin resistance by influencing hepatocyte nuclear factor 4a and regulating glucose transporter.