危重症患者ICU后心理功能障碍发生率及危险因素的Meta分析

Incidence and Risk Factors of Post-ICU Psychological Dysfunction in Critically Ill Patients:A Meta-analysis

目的总结危重症患者ICU后心理功能障碍的发生率和危险因素。方法系统检索PubMed、Embase、Cochrane library、中国知网、中国生物医学文献服务系统、万方数据库、维普等数据库,检索时限为建库至2023年1月,纳入关于ICU后心理功能障碍发生率及危险因素的文献并进行Meta分析。结果共纳入16篇文献,计167642例患者,ICU后心理功能障碍发生率为32%(95%CI:0.25~0.40)。患者年龄≤70岁、女性、学历水平高、饮酒史、脓毒症、慢性病史、精神疾病史、机械通气、ICU住院时间长、使用镇静剂、妄想记忆,事实记忆是ICU后心理功能障碍的危险因素(均P<0.05)。结论临床医护人员可根据以上危险因素采取相应干预措施,以降低ICU后心理功能障碍的发生率。

Objective To summarize the incidence and risk factors of post-ICU psychological dysfunction in critically ill patients.Methods The literatures were systematically retrieved from PubMed,Embase,Cochrane library,CNKI,SinoMed,Wanfang Data,and VIP,with the time period from the inception to January 2023.The studies on the incidence and risk factors of post-ICU psychological dysfunction were selected for Meta analysis.Results A total of 16 articles with 167,642 patients were included.The incidence of post-ICU psychological dysfunction was 32%(95%CI:0.25-0.40).Patient age≤70 years old,female,high level of education,history of alcohol drinking,sepsis,history of chronic disease,history of mental disease,mechanical ventilation,long stay in ICU,using tranquilizer,delusional memory,and factual memory were the risk factors of post-ICU psychological dysfunction(all P<0.05).Conclusions Clinical medical staff can provide corresponding interventions according to the above risk factors to reduce the incidence of post-ICU psychological dysfunction.