功能代谢组学在中药抗抑郁机制研究中的策略及应用

Research strategies and applications of functional metabolomics in anti-depressive mechanisms of traditional Chinese medicine

抑郁症(depression)是一种常见的情感障碍类疾病,在全世界范围内严重影响着人们的生命健康。抑郁症发病机制复杂,抗抑郁中药因其多成分、多途径、多靶点的作用方式,具有良好的治疗效果。目前,中药抗抑郁机制尚未完全阐明,但可以明确的是,抑郁症与代谢健康有着十分紧密的联系。因此,为深入挖掘中药抗抑郁机制,本文从代谢角度出发,提出了基于功能代谢组学策略的中药抗抑郁机制研究思路,即借助多组学联合分析技术探析抑郁症潜在生物标志物,同时开展抗抑郁中药功能性分子的研究,利用分子生物学技术精确捕获抑郁症特征代谢分子和抗抑郁中药功能性分子之间的分子相互作用,确定有效的药物靶点,进一步阐明抑郁症代谢紊乱所涉及的生化功能和相关机制。本文系统综述了功能代谢组学在中药抗抑郁机制中的研究策略及应用,阐述了功能代谢组学的核心价值,整理了近几年抗抑郁中药的研究现状和热点问题,以期借助功能代谢组学,为中药抗抑郁机制研究提供新方法、新思路。

Depression is a common emotional disorder that seriously affects people's life and health all over the world.The pathogenesis of depression is complex,and traditional Chinese medicine(TCM)for antidepressants has a good therapeutic effect because of its multi-component,multi-pathway,and multi-target action mode.At present,the anti-depressive mechanism of TCM has not been fully clarified,but it is clear that depression is closely related to metabolic health.Therefore,in order to further explore the anti-depressive mechanism of TCM,this paper proposes research strategies on the anti-depressive mechanism of TCM based on functional metabolomics from the perspective of metabolism,the potential biomarkers of depression are analyzed with the help of multiomics combined analysis technology,and the functional molecules of TCM for antidepressant are studied.Molecular biology techniques are used to accurately capture the molecular interactions between biomarkers of depression and functional compounds,which identify effective drug targets and further elucidate the biochemical functions and related mechanisms involved in depression metabolic disorders.This paper systematically reviews the research strategies and applications of functional metabolomics in the anti-depressive mechanisms of TCM,expounds on the core value of functional metabolomics,and summarizes the current research status and hot issues of TCM for antidepressants in recent years,providing new methods and new ideas for the study of mechanisms of TCM with the help of functional metabolomics.