家庭药师服务模式对PCI术后冠状动脉粥样硬化性心脏病患者用药依从性及有效性的影响

Effect of Family Pharmacist Service Model on Medication Compliance and Effectiveness in Patients with Coronary Heart Disease After PCI

目的探讨家庭药师服务模式对经皮冠脉介入术(PCI)术后冠状动脉粥样硬化性心脏病(CHD)患者用药依从性及有效性的影响。方法选取医院2019年12月至2020年12月收治的PCI术后CHD患者162例,按随机数字表法分为对照组(80例)和观察组(82例)。对照组患者接受常规出院用药教育及健康宣教,观察组患者在此基础上开展家庭药师服务模式。比较两组患者的用药依从性、药品不良反应发生率、主要心血管事件(心血管死亡、卒中、心肌梗死及非中枢神经系统栓塞)发生率及生活质量评分。结果观察组患者8条目Morisky用药依从性问卷评分为(6.80±0.73)分,显著高于对照组的(5.92±1.10)分(P<0.05);药品不良反应发生率为20.73%,显著低于对照组的68.75%(P<0.05);主要心血管事件发生率为9.76%,显著低于对照组的36.25%(P<0.05);健康状况调查简表(SF-36)心理健康、生理功能及社会功能评分均显著高于对照组(P<0.05)。结论家庭药师服务模式能有效提高PCI术后CHD患者的用药依从性及生活质量,降低药品不良反应及主要心血管事件的发生率。

Objective To investigate the effect of the family pharmacist service model on medication compliance and effectiveness in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods A total of 162 patients with CHD after PCI admitted to the hospital from December 2019 to December 2020 were selected and divided into the observation group(82 cases)and the control group(80 cases)by the random number table method.The patients in the control group were given routine guidelines and health education,on this basis,the patients in the observation group were given the family pharmacist service model.The medication compliance,incidence of adverse drug reactions,incidence of major cardiovascular events(cardiovascular death,stroke,myocardial infarction,and noncentral nervous system embolism),and quality of life scores between the two groups were compared.Results The 8-item Morisky Medication Adherence Scale(MMAS-8)in the observation group was(6.80±0.73)points,which was significantly higher than(5.92±1.10)points in the control group(P<0.05).The incidence of adverse drug reactions in the observation group was 20.73%,which was significantly lower than 68.75%in the control group(P<0.05).The incidence of major cardiovascular events in the observation group was 9.76%,which was significantly lower than 36.25%in the control group(P<0.05).The mental health,physiological function,and social function scores of the MOS 36-Item Short-Form Health Survey(SF-36)scale in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Family pharmacist service model can effectively improve the medication compliance and quality of life of patients with CHD after PCI,and reduce the incidence of adverse drug reactions and major cardiovascular events.