丁苯酞软胶囊联合银杏叶片对非痴呆性血管性认知障碍合并睡眠障碍患者的影响

Effects of Butylphthalide Soft Capsules Combined with Ginkgo Biloba Leaves Tablets on Patients with Vascular Cognitive Impairment Non-Dementia Complicated with Sleep Disorders

目的:观察丁苯酞软胶囊联合银杏叶片对非痴呆性血管性认知障碍(VCIND)合并睡眠障碍患者认知功能和炎症水平的影响。方法:选取2020年1月至2022年1月该院收治的92例VCIND合并睡眠障碍患者,采用随机数表法分为对照组和观察组,每组46例。对照组患者在常规治疗基础上口服丁苯酞软胶囊,观察组患者在常规治疗基础上口服丁苯酞软胶囊联合银杏叶片,连续治疗4周。治疗结束后,采用蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)和匹斯堡睡眠质量指数量表(PSQI)评估患者的认知功能和睡眠质量,采用经颅多普勒(TCD)检测患者的脑血流速度;检测患者血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)水平;观察治疗过程中不良反应发生情况。结果:治疗后,两组患者的MMSE评分、MoCA评分和脑血流速度均显著升高,且观察组患者显著高于对照组,差异均有统计学意义(P<0.05);两组患者的PSQI评分,TNF-α、IL-6和IL-8水平显著降低,且观察组患者显著低于对照组,差异均有统计学意义(P<0.05)。治疗过程中,观察组、对照组患者的不良反应发生率分别为8.70%(4/46)、6.52%(3/46),差异无统计学意义(P>0.05)。结论:丁苯酞软胶囊联合银杏叶片能够提高VCIND合并睡眠障碍患者的认知功能和睡眠质量,并能提高脑血流速度,降低血清炎症因子水平。

OBJECTIVE:To observe the effects of Butylphthalide soft capsules combined with Ginkgo biloba leaves tablets on the cognitive function and inflammation levels in patients with vascular cognitive impairment non-dementia(VCIND)complicated with sleep disorders.METHODS:A total of 92 patients with VCIND complicated with sleep disorders admitted into our hospital from Jan.2020 to Jan.2022 were selected and divided into control group and observation group by random number table method,with 46 cases in each group.The control group was given Butylphthalide soft capsules on the basis of conventional treatment,while the observation group received Butylphthalide soft capsules combined with Ginkgo biloba leaves tablets on the basis of conventional treatment,with continuous treatment for 4 weeks.After treatment,the cognitive function and sleep quality of patients were assessed by the Montreal Cognitive Assessment scale(MoCA),Mini-Mental State Examination(MMSE)and Pittsburgh Sleep Quality Index scale(PSQI).Cerebral blood flow velocity was measured by transcranial Doppler(TCD).Serum levels of tumor necrosis factorα(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)and adverse drug reactions were detected.RESULTS:After treatment,the MMSE score,MoCA score and cerebral blood flow velocity increased significantly in both groups,and the observation group was significantly higher than the control group,with statistically significant difference(P<0.05).The PSQI score,levels of TNF-α,IL-6 and IL-8 in both groups decreased significantly,and the observation group was significantly lower than the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the observation group and control group was respectively 8.70%(4/46)and 6.52%(3/46),with no statistical significance(P>0.05).CONCLUSIONS:Butylphthalide soft capsules combined with Ginkgo biloba leaves tablets could improve the cognitive function and sleep quality of patients with VCIND complicated with sleep disorders,increase the cerebral blood flow velocity and reduce the level of serum inflammatory factors.