化浊祛毒健脾法治疗早期2型糖尿病对胰岛α/β细胞及氧化应激的影响

Effect of Huazhuo Qudu Jianpi Therapy on Pancreatic α/β Cells and Oxidative Stress in Early Type 2 Diabetes Mellitus

目的 通过观察化浊祛毒健脾法联合二甲双胍治疗早期2型糖尿病对胰岛α/β细胞及氧化应激的影响,进一步探究化浊祛毒法可能的降糖作用机制。方法 选取2020年1月—2021年6月163例早期2型糖尿病患者,随机分为两组,其中对照组81例,试验组82例。两组患者均予基础饮食及运动管理,合并有基础疾病分别给予相应治疗。对照组予二甲双胍,试验组予化浊祛毒健脾方联合二甲双胍治疗,观察疗程为48周。主要观察两组患者治疗前后临床疗效、血清胰高血糖素样肽-1(GLP-1)浓度、胰高血糖素(GC)浓度、空腹C肽(CP)水平、氧化应激指标超氧化物歧化酶(SOD)、空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白水平(HbAlc)指标变化。结果 治疗后,临床疗效方面,试验组总有效率为90.24%,高于对照组的74.07%,差异有统计学意义(P<0.05);在糖代谢方面,试验组FPG、PBG、HbAlc水平明显低于对照组,差异有统计学意义(P<0.05);试验组空腹C肽水平明显高于对照组,差异有统计学意义(P<0.05);试验组GLP-1水平较对照组明显更高,差异有统计学意义(P<0.05),且治疗后试验组的GC水平低于对照组,差异有统计学意义(P<0.05);试验组SOD水平较对照组明显更高,差异有统计学意义(P<0.05)。结论 化浊祛毒健脾法联合二甲双胍治疗可明显改善早期2型糖尿病患者的血糖谱,并可提高血清GLP-1、空腹C肽及SOD水平,并抑制胰岛α细胞分泌胰高血糖素,有助于保护胰岛β细胞并促进其功能恢复。

Objective To observe the effect of Huazhuo Qudu Jianpi therapy combined with metformin on pancreatic isletα/βcells in early type 2 diabetes,further explore the possible hypoglycemic mechanism of Huazhuo Qudu Jianpi therapy.Methods From January 2020 to May 2021,163 patients with early type 2 diabetes were selected and randomly divided into two groups:control group(n=81)and experimental group(n=82).Two groups of patients were given basic diet and exercise management,and corresponding treatment with basic diseases.The control group was treated with metformin,and Huazhuo Qudu Jianpi Decoction(化浊祛毒健脾方)combined with metformin was given to the Huazhuo Qudu Jianpi group.The observation course lasted for 48 weeks.And mainly observed two groups of patients before and after treatment clinical curative effect,serum glucagon like peptide 1(GLP-1)concentration,concentration of glucagons(GC),fasting C peptide(CP)level,oxidative stress,superoxide dismutase(SOD),fasting plasma glucose(FPG),postprandial 2 hours blood glucose(PBG),glycosylated hemoglobin(HbAlc)index changes.Results After treatment,in terms of clinical efficacy,the total effective rate of the experimental group was 90.24%,which was higher than 74.07% of the control group,with a statistically significant difference(P<0.05);In terms of glucose metabolism,the levels of FPG,PBG,and HbAlc in the experimental group were significantly lower than those in the control group,with statistical significance(P<0.05);The fasting C-peptide levels in the experimental group were significantly higher than those in the control group,with a statistically significant difference(P<0.05);The GLP-1 level in the experimental group was significantly higher than that in the control group,with a statistically significant difference(P<0.05),and the GC level in the experimental group was lower than that in the control group after treatment,with a statistically significant difference(P<0.05);The SOD level in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Huazhuo Qudu Jianpi therapy combined with metformin can significantly improve the blood glucose spectrum of early type 2 diabetes patients,and can increase the levels of serum GLP-1,fasting C-peptide and SOD,and inhibit the secretion of glucagon by pancreaticαcells,which is helpful to protect pancreaticβcells and promote their functional recovery.