基于肠道菌群探讨2型糖尿病从脾论治作用机制

Study on Mechanism of Type 2 Diabetes from Spleen Treatment Based on Intestinal Flora

2型糖尿病是常见的代谢性疾病,近年来发病率逐渐升高。目前在临床上,中医药治疗2型糖尿病的口服药效果良好,肠道菌群在药物的治疗过程中发挥着重要作用。研究表明,肠道菌群的失调可促进2型糖尿病的发生,肠道微生物菌群被认为是2型糖尿病诊断及治疗的新靶点,故通过调节肠道菌群种类及数量的平衡可对2型糖尿病起到治疗作用。中医认为“脾主运化”,脾为“后天根本”,肠道菌群的稳定是“脾主运化”功能正常的基础。脾虚易致消渴,并导致胰岛素抵抗,通过健脾助运之法可调整脾虚型2型糖尿病患者肠道菌群的数量和结构,加强机体免疫,对2型糖尿病起到很好的治疗效果。该文从肠道菌群—脾的机制对2型糖尿病进行了分析,以期为中医学治疗2型糖尿病提供新思路和理论基础。

Type 2 diabetes is a common metabolic disease.In recent years,the incidence rate has gradually increased.At present,traditional Chinese medicine has a good oral effect in the clinical treatment of type 2 diabetes,and intestinal flora plays an important role in the treatment process of drugs.Studies have shown that the imbalance of intestinal flora can promote the occurrence of type 2 diabetes.Intestinal microbiota is considered as a new target for the diagnosis and treatment of type 2 diabetes.Therefore,it can play a therapeutic role for type 2 diabetes by regulating the balance of intestinal flora types and numbers.Traditional Chinese medicine believes that“spleen dominates the movement”is the“acquired root”,and the stability of intestinal flora is the basis for the normal function of“spleen dominates the movement”.Spleen deficiency can easily lead to thirst reduction and insulin resistance.The method of strengthening the spleen and assisting the circulation can improve the number and structure of intestinal flora of type 2 diabetes patients with spleen deficiency,strengthen the body immunity,and play a very good therapeutic effect on type 2 diabetes.This paper analyzes type 2 diabetes from the mechanism of intestinal flora spleen,in order to provide a new idea and theoretical basis for the treatment of type 2 diabetes in traditional Chinese medicine.