心肌纤维化在高血压心脏病中的研究进展

Myocardial Fibrosis in Hypertensive Heart Disease

高血压是导致全球心血管疾病死亡及致残的首要危险因素,长期血压控制不佳会导致高血压心脏病。心肌纤维化是高血压心脏病的重要组成部分,是一种由多种因素综合影响的疾病。现对心肌纤维化病理生理机制进展做进一步探求,为早期识别纤维化,寻找更精准的药物治疗靶点,进而为延缓甚至逆转高血压心脏病的不良结局提供可能。

Hypertension is the primary risk factor leading to death and disability of cardiovascular disease in the world,and poor long-term blood pressure control will lead to hypertensive heart disease.Myocardial fibrosis is an important component of hypertensive heart disease,which is a disease influenced by multiple factors.Further exploration of the pathological and physiological mechanisms of myocardial fibrosis provides the possibility for early identification of fibrosis,finding more precise drug treatment targets,and delaying or even reversing the adverse outcomes of hypertensive heart disease.