干细胞来源外泌体miRNA介导心脏修复的研究进展

Exosomal miRNA Derived from Stem Cell in Mediating Cardiac Repair

在过去几十年中,急性心肌梗死采用开通罪犯冠状动脉和血运重建术等新技术已经显著改善了心肌梗死的预后,但仍有许多患者心肌梗死后出现不良的心脏重构及心力衰竭。随着心力衰竭的流行,急需一种新的治疗方法,无细胞疗法是一种很有前途的治疗方法,在多种急慢性心脏病中调节并促进心脏修复。现就干细胞来源外泌体微RNA在心肌损伤后介导心脏修复的研究进展进行综述。

Although new technologies such as opening criminal coronary arteries and revascularization have markedly enhanced the prognosis of acute myocardial infarction in recent decades,several patients still have poor cardiovascular remodeling and heart failure after myocardial infarction.With the prevalence of heart failure,there is an urgent need for a new approach to treatment.Cellular-free therapy is a promising therapeutic approach that has prospects for regulating and promoting cardiac repair in a variety of acute and chronic heart diseases.This review examines progress of exosomal miRNA derived from stem cell in mediating cardiac repair after myocardial lesion.