纳米氧化铈抗氧化保护心肌细胞的研究进展

Cerium Oxide Nanoparticles in Antioxidant Protection of Myocardial Cells

纳米氧化铈(CeNPs)是一种很强的自由基清除剂。研究表明,CeNPs可预防炎症导致的氧化应激,也可调节免疫反应缓解炎症。炎症期间,不同的免疫反应具有明显不同的能量需求。过量的活性氧会造成氧化应激,而线粒体或其他细胞内来源产生的活性氧在心肌细胞缺血再灌注损伤的发病机制中起关键作用,CeNPs因其具有极好的氧缓冲能力及生物可降解性,目前在抗氧化研究中受到极大关注。现综述国内外CeNPs抵抗氧化应激、保护心肌细胞的具体机制,可能为CeNPs在临床心血管疾病的治疗中提供新的理论依据。

Cerium oxide nanoparticles(CeNPs)are a powerful free radical scavenger.Studies have shown that CeNPs can prevent oxidative stress caused by inflammation,and can also regulate immune response to alleviate inflammation.During inflammation,the different immune responses have obviously different energy requirements.Excessive reactive oxygen species can cause oxidative stress,and reactive oxygen species produced by mitochondria or other intracellular sources play a key role in the pathogenesis of myocardial ischemia reperfusion injury.CeNPs have attracted great attention in antioxidant research because of their excellent oxygen buffering capacity and biodegradability.In this paper,the specific mechanism of CeNPs resisting oxidative stress and protecting myocardial cells at home and abroad is discussed,which provides a new theoretical basis for CeNPs in the treatment of clinical cardiovascular diseases.