止嗽散合三拗汤对百日咳血清炎症因子及肠黏膜屏障功能的影响

Effects of Zhisou Powder(止嗽散)and San'ao Decoction(三拗汤)on Serum Inflammatory Factors and Intestinal Mucosal Barrier Function in Infants with Pertussis

探讨止嗽散合三拗汤对百日咳患儿血清炎症因子及肠黏膜屏障功能的影响。方法 选取诊治的百日咳患儿60例,随机分为对照组与观察组,每组30例,对照组常规西药治疗,观察组在对照组治疗基础上给予止嗽散合三拗汤治疗,治疗时间2周,观察患儿症状的改善情况及血清白细胞介素-2(interleukin-2,IL-2)、白细胞介素-4(interleukin-4,IL-4)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor α,TNF-α)、γ干扰素(interferon-γ,INF-γ)、晚期糖基化终末产物(advanced glycation end products, AGEs)、内毒素(endotoxin, ETX)、二胺氧化酶(diamine oxidase, DAO)变化。结果 观察组发热消失时间、喘息消失时间、痉挛性咳嗽消失时间、肺部罗音消失时间短于对照组,差异有统计学意义(P<0.001)。治疗前血清IL-2、IL-4、IL-6、TNF-α、INF-γ水平,两组之间比较差异无统计学意义(P>0.05),治疗后血清IL-4、IL-6、TNF-α、INF-γ水平,与治疗前组内比较下降(P<0.001),同时观察组低于对照组(P<0.001),治疗后血清IL-2水平与治疗前组内比较升高,同时观察组高于对照组(P<0.05)。治疗前血清AGEs、ETX、 DAO水平,两组之间比较差异无统计学意义(P>0.05),治疗后血清AGEs、ETX、 DAO水平,与治疗前组内比较下降(P<0.001),同时观察组低于对照组(P<0.001)。观察组治疗疗效整体优于对照组(P<0.05),治疗总有效率为93.33%(28/30)高于对照组(70.00%,21/30)(P<0.05)。结论 止嗽散合三拗汤治疗百日咳疗效较好,可有助于改善血清炎症因子及肠黏膜屏障功能,提高疗效。

Objective To investigate the effects of Zhisou Powder(止嗽散)and San'ao Decoction(三拗汤)on serum inflammatory factors and intestinal mucosal barrier function in infants with pertussis.Methods Sixty infants with pertussis were randomly divided into control group and observation group and each group had 30 cases.The infants in the control group were treated with routine western medicine and those in the observation group were treated with Zhisou Powder and San'ao Decoction on the basis of control group.The treatment lasted for 2 weeks.The improvement of symptoms and serum levels of interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),γ-interferon(INF-γ),advanced glycation end products(AGEs),endotoxin(ETX)and diamine oxidase(DAO)were detected before and after treatment.Results The disappearance time of fever,wheezing,spasmodic cough and pulmonary rales in the observation group was shorter than that in the control group(P<0.001).There were no significant difference in serum levels of IL-2,IL-4,IL-6,TNF-αor INF-γbetween the two groups before treatment(P>0.05).The levels of IL-4,IL-6,TNF-αand INF-γdecreased after treatment compared with those before treatment in the two groups(P<0.05)and the levels in the observation group were lower than those in the control group(P<0.001).The levels of IL-2 increased after treatment compared with those before treatment in the two groups(P<0.001)and the level in the observation group was higher than that in the control group(P<0.001).There were no significant difference in serum levels of AGEs,ETX or DAO between the two groups(P>0.05).The levels of AGEs and ETX and DAO decreased after treatment compared with those before treatment in the two groups(P<0.001)and the levels in the observation group were lower than those in the control group(P<0.001).The therapeutic effect of the observation group was better than that in the control group(P<0.05),and the total effective rate was 93.33%(28/30),higher than that(70.00%,21/30)of the control group(P<0.05).Conclusion Zhisou Powder and San'ao Decoction have better curative effect on pertussis.It can improve serum inflammatory factors and intestinal mucosal barrier function,and improve the therapeutic effect.