下一代测序技术在癌症诊疗中的应用及研究进展

Advances in Cancer Diagnosis and Treatment Based on NGs Technology

下一代测序(NGS)在癌症诊疗中扮演着日益重要的角色,继在临床中广泛普及的伴随诊断应用之后,基于循环肿瘤DNA(ct DNA)的液体活检技术近年来发展迅速,并有望在高危人群癌症早筛和患者术后微小残留病灶(MRD)检测方面发挥重要作用。综述NGS与癌症临床相关的最新应用和研究进展,并探讨其现有临床价值和发展前景。

Next-generation sequencing(NGS)is becoming increasingly important in cancer diagnosis and treatment.Following the widespread application of NGS in companion diagnostics,liquid biopsy based on circulating tumor DNA(ctDNA)is now rapidly advancing,and it has been proven to be a promising method in early screening of cancer and post-surgery minimal residual disease(MRD)detection.This review introduces the latest NGS applications and advances relating to cancer clinical intervention and research,and discusses its current clinical valueand future prospects.