免疫检查点B7-H3在癌症中作用研究进展

Advancein Researchon the Function of Immune Checkpoint B7-H3 in Cancer

免疫检查点是指在免疫细胞上表达,能调节免疫激活程度的一系列分子,其对调节免疫作用至关重要。越来越多的免疫检查点被发现在癌细胞上有异常表达,并与癌症进展密切相关。基于这些免疫检查点,许多靶向药物被开发,如抗体药物、嵌合抗原受体T细胞(CAR-T)、抗体偶联药物(ADC)等。B7-H3是近年来发现的新免疫检查点,在多种肿瘤组织上均发现有异常表达,其不仅具有免疫调节功能,也能通过一些非免疫机制促使肿瘤细胞增生、逃逸免疫反应、产生耐药性和转移。综述B7-H3在癌症进展中发挥的作用及其机制研究进展,以期为靶向B7-H3新药的开发提供参考。

Immune checkpoints are molecules present on the surface of immune cells,and are critical in regulating immune responses.In recent years,a large number of immune checkpoints have been identified as abnormally expressed on cancer cells,and have been found to be closely associated with tumor progression.Based on those immune checkpoints,many anticancer therapies,e.g.mAbs,chimeric antigen receptor T cells(CAR-T),and antibody conjugated drug(ADC),have been developed.B7-H3,a newly discovered immune checkpoint ubiquitously expressed by cancer tissues,is capable of driving tumor proliferation,immune evasion,drug resistance and metastasis.In an effort to provide some reference for drug development,this review summarizes recent studies of B7-H3 with its effects and mechanisms.