摘要
肠肝脑轴在帕金森病(Parkinson’s disease,PD)发病中的机制是目前研究的热点。α-突触核蛋白(α-syn)、脂多糖(LPS)、短链脂肪酸(SCFAs)通过轴的神经免疫及内分泌免疫路径,扮演着诱发PD的关键角色,而胃肠道(GI)功能紊乱的微生物群(GM)更是充当着“始作俑者”。肠肝脑轴整体网络化、动态演变化的特点突破了以往PD研究的单因素局限性。故而借助已有成果,综合分析轴内系统化分子信号,以期助力PD机制研究的进展。
The mechanism of the gut-liver-brain axis in the pathogenesis of Parkinson’s disease(PD)is a current research hotspot,α-synuclein(α-syn),lipopolysaccharide(LPS),and short-chain fatty acids(SCFAs)play key roles in inducing PD through the axis of neuroimmune and endocrine immune pathways,while gastrointestinal(GI)function The disordered microbiota(GM)acts as the“initiator”.The characteristics of the overall network and dynamic evolution of the gut-liver-brain axis have broken through the single-factor limitation of previous PD studies.Therefore,with the help of existing achievements,comprehensive analysis of intraaxial systemic molecular signals is expected to facilitate the progress of PD mechanism research.
作者
李斐
梁建庆
韩政阳
董海玉
王佳华
许晨璐
LI Fei;LIANG Jianqing;HAN Zhengyang;DONG Haiyu;WANG Jiahua;XU Chenlu(Gansu University of Traditional Chinese Medicine,Gansu Lanzhou 730000,China;The Key Laboratory of the Ministry of Education of Dunhuang Medicine and Transformation,Gansu Lanzhou 730000,China;Gansu Provincial Key Laboratory of Traditional Chinese Medicine Prescription Excavation and Innovation Transfor mation,Gansu Lanzhou730000,China)
出处
《中医药临床杂志》
2023年第7期1258-1263,共6页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金(No.81660767,No.82160929)
2021年度甘肃省科技厅第十一批省级科技计划自然科学基金(自筹经费)项目(21JR11RA143)
2021年度甘肃省教育厅青年博士基金项目(2021QB-077)
敦煌医学与转化教育部重点实验室开放课题(No.DHYX18-08)
甘肃省中医药研究中心开放课题(zyzx-2020-zx20)。
关键词
帕金森病
肠肝脑轴
发病机制
Parkinson’s disease
Gut-liver-brain axis
Pathogenesis
