红树林植物内生真菌次级代谢产物研究进展(2018-2019年)

Research progress on the secondary metabolites produced by endophytic fungi isolated from mangrove plants(2018-2019)

红树林植物长期处于高盐、缺氧、频繁潮汐等独特环境,其内生真菌与宿主植物共同进化,从中挖掘出了许多结构新颖的功能分子,是天然产物先导化合物发现的重要来源。本文综述了2018年1月—2019年12月发现的来源于红树林植物内生真菌的次级代谢产物,重点总结了它们的化学结构类型、宿主来源。描述化合物460个,其中新化合物217个,出新率达47.2%;结构类型涉及聚酮类、萜类、生物碱;研究较多的菌属为曲霉属Aspergillus、间座壳属Diaporthe、青霉属Penicillium、枝孢属Cladosporium;研究较多的宿主植物为秋茄、红海榄、海莲、角果木。本文旨在总结本领域的研究成果与存在问题,为今后研究提供参考。

Mangrove plants have long been in a unique environment such as high salinity,hypoxia,and frequent tides.Their endophytic fungi co-evolved with their host plants,and many functional molecules with novel structures have been unearthed.They are important source of lead compounds of natural products.This paper reviews the secondary metabolites produced by endophytic fungi derived from mangrove plants from the beginning of 2018 to the end of 2019,with emphasis on compounds’structural types and host sources.460 compounds are described,including 217 new compounds(47.2%).Structural types involve polyketides,terpenes,and alkaloids.The main producing strains are affiliated to genera such as Aspergillus,Diaporthe,Penicillium,and Cladosporium.The main host plants are Kandelia candel,Rhizophora stylosa,Bruguiera sexangula,and Ceriops tagal.Research progress and open questions are summarized and discussed to provide references for future research in the paper.