成年人Life's Simple 7和非酒精性脂肪性肝病之间的关联

Association between Life's Simple 7 and Nonalcoholic Fatty Liver Disease in Adults

目的探究成年人中Life's Simple 7与非酒精性脂肪性肝病(NAFLD)之间的关联。方法数据来自2017-2018年国家健康和营养检查调查(NHANES)中招募的成年人。排除HBsAg阳性、抗-HCV阳性和大量饮酒后,通过肝脏振动控制瞬时弹性成像(VCTE)对NAFLD进行诊断。参考既往的研究计算Life's Simple 7,0~8分为低分组(inadequate),9~10分为平均组(average),11~14分为优秀组(optimal)。进行多因素Logistic回归分析相关性。结果分析了2376名参与者的数据。NAFLD的总患病率为42.0%,在inadequate、average和optimal评分类别中的患病率分别为62.5%、33.4%和10.8%(P<0.001)。多因素Logistics回归分析,调整了年龄、性别、种族和贫困收入比率(PIR)后显示Life's Simple 7得分越高,NAFLD患病风险降低。跟inadequate组对比,average组OR值为0.31(95%CI:0.23-0.42),optimal组的OR值为0.08(95%CI:0.05-0.13)。根据分层分析,这种关联在不同年龄、性别、种族和经济群体中是相似的。结论越高的Life's Simple 7评分与越低的NAFLD患病率相关。拥有理想的心血管健康指标可能有利于降低普通成年人NAFLD的患病率。

Objective To explore the relationship between Life's Simple 7 and nonalcoholic fatty liver disease(NAFLD)in adults.Methods Data are from adults recruited in the National Health and Nutrition Examination Survey(NHANES)from 2017 to 2018.After excluding HBsAg positive,anti-HCV positive and heavy drinking,NAFLD was diagnosed by liver vibration control transient elastography(VCTE).Refer to previous studies to calculate Life's Simple 7,0-8 points are inadequate,9-10 points are average,and 11-14 points are optimal.Multi-factor Logistic regression was used to analyze the correlation.Results The data of 2376 participants were analyzed.The total prevalence of NAFLD was 42.0%,and the prevalence of NAFLD was 62.5%,33.4%and 10.8%in the categories of inadequate,average and optimal scores,respectively(P<0.001).Multivariate Logistic regression analysis,adjusted for age,sex,race and poverty income ratio(PIR),showed that the higher the score of Life's Simple 7,the lower the risk of NAFLD.Compared with inadequate group,the OR value of average group was 0.31(95%CI:0.23-0.42),and the OR value of optimal group was 0.08(95%CI:0.05-0.13).According to the hierarchical analysis,this association is similar in different age,gender,race and economic groups.Conclusion The higher the Life's Simple 7 score,the lower the prevalence of NAFLD.Having ideal cardiovascular health indicators may help reduce the prevalence of NAFLD in general adults.