摘要
Glioblastoma(GBM)is a malignant adult brain tumor for which 90%of patients experience recurrence within a year after surgery1.Evolution confers treatment resistance capabilities on tumors2.The diversification of malignant and non-malignant(i.e.,stromal and immune cell)compartments in the tumor microenvironment(TME)during tumor evolution3-7 eventually results in the formation of a complex interaction network that promotes tumor progression.
基金
supported by grants from the National Natural Science Foundation of China(Grant Nos.91959113,81972358,82261160578,and 82272867)
the Beijing Nova Program(Grant No.Z201100006820118)。
