盆炎清方治疗慢性盆腔炎疗效及对MCP-1、T细胞亚群的变化研究

Study on Curative Effect of Panyanqing Formula(盆炎清方)on Patients with Chronic Pelvic Inflammatory Disease and Changes of MCP-1 and T Cell Subsets

目的研究盆炎清方对慢性盆腔炎患者的疗效及血清单核细胞趋化蛋白1(monocyte chemotaxis protein-1,MCP-1)、T细胞亚群的变化。方法选取医院2020年8月—2021年12月收治的慢性盆腔炎患者118例,根据随机原则分为抗生素组和盆炎清组,单组59例。抗生素组给予常规抗生素药物治疗,盆炎清组加用盆炎清方治疗,分析两组治疗后的临床疗效。结果盆炎清组总有效率为91.53%(54/59),抗生素组为76.27%(45/59),盆炎清组患者总有效率高于抗生素组(P<0.05)。两组治疗前中医证候积分组间比较,差异无统计学意义(P>0.05)。盆炎清组治疗3个周期后中医证候积分[(7.10±1.22)分]低于抗生素组[(14.23±2.96)分],差异有统计学意义(P<0.05)。两组治疗前MCP-1、粒-巨核细胞集落刺激因子(Granulocyte megakaryocyte colony stimulating factor,GM-CSF)、白细胞介素-17(Interleukin-17,IL-17)、T细胞亚群(CD^(+)_(4)、CD^(+)_(8)、CD^(+)_(4)/CD^(+)_(8))水平组间比较,差异无统计学意义(P>0.05)。盆炎清组治疗3个周期后MCP-1、GM-CSF、IL-17水平及T细胞亚群优于抗生素组(P<0.05)。结论盆炎清方治疗慢性盆腔炎可降低患者MCP-1、GM-CSF、IL-17的表达水平,改善中医证候积分,提高免疫功能。

Objective To study the efficacy of Panyanqing Formula(盆炎清方)in the treatment of chronic pelvic inflammatory disease and the changes of serum monocyte chemoattractant protein 1(MCP-1)and T cell subsets.Methods A total of 118 pa⁃tients with chronic pelvic inflammatory disease admitted to the hospital from August 2020 to December 2021 were selected and randomly divided into antibiotic group and Panyanqing Formula group,with 59 cases in each group.The antibiotic group was trea⁃ted with conventional antibiotics,and the Panyanqing Formula group was additionally treated with Panyanqing Formula.The clini⁃cal efficacy of the two groups after treatment was analyzed.Results The total effective rate was 91.53%(54/59)in the Panyan⁃qing Formula group and 76.27%(45/59)in the antibiotic group.The total effective rate in the Panyanqing Formula group was higher than that in the antibiotic group(P<0.05).There was no significant difference in TCM syndrome scores between the two groups before treatment(P>0.05).After 3 cycles of treatment,the score of TCM syndromes in the Panyanqing Formula group[(7.10±1.22)points]was lower than that in the antibiotic group[(14.23±2.96)pints],and there was statistically significant difference(P<0.05).Comparison of the levels of MCP-1,granulocyte-megakaryocyte colony-stimulating factor(GM-CSF),interleukin-17(IL-17),T cell subsets(CD^(+)_(4),CD^(+)_(8),CD^(+)_(4)/CD^(+)_(8))between the two groups before treatment had no statis⁃tically significant difference(P>0.05).The levels of MCP-1,GM-CSF,IL-17 and T cell subsets in the Panyanqing Formula group were better than those in the antibiotic group after 3 cycles of treatment(P<0.05).Conclusion The treatment of chronic pelvic inflammation with Panyanqing Formula can reduce the expression levels of MCP-1,GM-CSF and IL-17,improve the scores of TCM syndromes and improve the immune function.