阿戈美拉汀联合中药熏蒸治疗老年抑郁伴失眠患者的临床效果

Clinical effect of agomelatine combined with traditional Chinese medicine fumigation on elderly patients with depression and insomnia

目的观察阿戈美拉汀联合中药熏蒸治疗老年抑郁(LLD)伴失眠患者的临床效果。方法选取住院的老年抑郁伴失眠患者76例纳入研究,随机数字表法分为常规治疗组(38例)和观察组(38例)。常规治疗组给予阿戈美拉汀口服,观察组在此基础上给予中药熏蒸治疗,治疗8周。观察治疗后汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠指数量表(PSQI)评分的变化,同时观察血清Hcy变化趋势。结果治疗前,两组患者的HAMD、PSQI及Hcy结果对比无明显差异(P<0.05);治疗8周后,观察组的治疗总有效率高于常规治疗组,睡眠改善率高于常规治疗组(P<0.05)。两组患者治疗后Hcy浓度低于治疗前(P<0.05),治疗后观察组Hcy浓度低于常规治疗组(P<0.05)。结论中药熏蒸疗法可有效提升老年抑郁伴失眠患者的临床疗效、改善患者睡眠,且具有安全、副作用小、患者体验舒适等优点,值得临床推广。

Objective To observe the clinical efficacy of agomelatine combined with traditional Chinese medicine fumigation in the treatment of LLD patients with insomnia.Methods 76 elderly patients with depression and insomnia hospitalized were included in the study.They were randomly divided into routine treatment group(38 cases)and observation group(38 cases).The routine treatment group was given oral administration of agomelatine,while the observation group was given fumigation with traditional Chinese medicine for 8 weeks.Observe the changes of HAMD and PSQI score after treatment,and observe the change trend of Hcy.Results Before treatment,there was no significant difference in HAMD,PSQI and Hcy between the two groups(P<0.05).After 8 weeks of treatment,the total effective rate of the observation group was higher than that of the conventional treatment group,and the sleep improvement rate was higher than that of the conventional treatment group(P<O.05).The Hcy concentration in the two groups after treatment was lower than that before treatment(P<0.05),and that in the observation group after treatment was lower than that in the conventional treatment group(P<0.05).Conclusion Traditional Chinese medicine fumigation therapy can effectively improve the clinical efficacy and sleep of elderly patients with depression and insomnia,and has the advantages of safety,less side effects and comfortable experience,which is worthy of clinical promotion.