七氟烷与丙泊酚对老年乳腺癌术后患者认知功能及负性情绪的影响分析

The distinction of sevoflurane and propofol on cognitive function and negative emotions in elderly breast cancerpatients aftersurgery

目的探讨七氟烷与丙泊酚对老年乳腺癌手术后患者认知功能及负性情绪的影响。方法本研究对象为2019年4月~2022年4月我院100例老年乳腺癌患者,均采用乳腺癌根治手术,随机分为两组,即七氟烷组与丙泊酚组,术中麻醉维持分别采用持续吸入七氟烷以及靶控输注丙泊酚。比较两组患者术前、术后简明精神状态量表(MMSE)、焦虑自评量表(SAS)、抑郁自评量表(SDS),记录术后躁动、认知功能障碍等并发症发生率。结果两组术后MMSE评分均显著低于术前,且术后丙泊酚组显著高于七氟烷组(P<0.05);两组术后SAS评分、SDS评分显著高于术前,且术后丙泊酚组显著低于七氟烷组(P<0.05);丙泊酚组术后认知功能障碍、谵妄发生率显著低于七氟烷组(P<0.05),躁动发生率差异无统计学意义(P>0.05)。结论七氟烷与丙泊酚用于老年乳腺癌手术时,丙泊酚术后认知功能损害以及负性情绪更轻,能够降低躁动、认知功能障碍等并发症发生率。

Objective To investigate the distinction of sevoflurane and propofol on cognitive function and negative emotions in elderly breast cancer patients after surgery.Methods A total of 100 elderly breast cancer patients in our hospital from April 2019 to April 2022 were the subjects of this study,and all of whom underwent radical breast cancer surgery.They randomly divided into the two groups,namely sevoflurane group and propofol group.Intraoperative anesthesia was maintained by continuous inhalation of sevoflurane and target-controlled infusion of propofol,respectively.The two groups were compared before and after operation with Brief Mental State Scale(MMSE),Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS).Postoperative agitation,cognitive dysfunction and other complications were recorded.Results The postoperative MMSE scores in both groups were significantly lower than those before surgery,and the postoperative propofol group was significantly higher than that in the sevoflurane group(P<0.05).The postoperative SAS and SDS scores of the two groups were significantly higher than those before surgery,and the postoperative propofol group was significantly lower than that of the sevoflurane group(P<0.05).The incidences of postoperative cognitive dysfunction and delirium in the propofol group were significantly lower than those in the sevoflurane group(P<0.05).There was no significant difference in the incidence of agitation(P>0.05).Conclusion When sevoflurane and propofol are used in elderly breast cancer surgery,the postoperative cognitive impairment and negative emotions after propofol are less severe,which can reduce the incidence of complications such as restlessness and cognitive dysfunction.