3型固有淋巴样细胞在免疫系统进化中的作用研究现状

The role of group 3 innate lymphoid cells(ILC3)in the evolution of the immune system:An update

3型固有淋巴样细胞(ILC3)是ILC的一个亚群,以表达维甲酸相关孤核受体γt(RORγt)及白细胞介素22(IL-22)为特征。我们总结了ILC3在协调固有免疫和适应性免疫中的作用,并从免疫系统进化的角度解释了ILC3的意义。此外,基于免疫相关功能,我们提出ILC3出现在免疫系统进化中的可能时间、当前研究中的不足及未来的可能研究方向。

Group 3 innate lymphoid cells(ILC3)are an ILC subset that is characterized by the expression of retinoic acid-related orphan nuclear receptor yt(RORyt)and interleukin 22(IL-22).This review summarizes the role of ILC3 in coordinating innate immunity and adaptive immunity based on current research and elaborate the significance of ILC3 from the perspective of immune system evolution.In addition,based on immune-related functions,we propose a possible time when ILC3 appears in the evolution of the immune system.And then,the research limitations and prospects are discussed.