气道上皮中pendrin的研究进展

Progress of pendrin in airway epithelia

Pendrin是一种电中性的离子交换转运蛋白,在气道上皮中主要表达于上皮细胞膜的顶端,负责氯离子(Cl^(-))的重吸收并交换碳酸氢根(HCO_(3)^(-))或硫氰酸根(SCN^(-))至管腔液,主要参与调节气道表面液体层(airway surface liquid,ASL)的酸碱度和厚度、黏蛋白分泌及气道防御过程,对于维持气道表面微环境的稳态具有重要意义。在支气管哮喘中,pendrin的表达明显上调,与支气管哮喘的重要病理过程如气道高反应性、中性粒细胞浸润和黏蛋白分泌增加密切相关。抑制pendrin的功能可能是支气管哮喘治疗的新靶点。

Pendrin is an electroneutral anion exchanger transporter,residing in the apical region of airway epithelium cells.It is responsible for the reabsorption of chloride(Cl^(-))and the exchange of bicarbonate(HCO_(3)^(-))or thiocyanate(SCN^(-))to the lumen.It is mainly involved in regulating the pH and thickness of airway surface liquid(ASL),mucin secretion,and airway defense,which is of great significance for maintaining the stability of the airway surface microenvironment.The expression of pendrin is significantly up-regulated in bronchial asthma,which is closely related to the pathological processes of the lung in bronchial asthma,such as airway hyperresponsiveness,neutrophil infiltration,and increased mucin secretion.Inhibiting the function of pendrin may be a new target for the treatment of bronchial asthma.