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未折叠蛋白反应在急性呼吸窘迫综合征中的研究进展

Progress of unfolded protein response in acute respiratory distress syndrome
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摘要 急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是儿童的严重呼吸系统疾病,发病机制尚未完全明确,主要与各种肺损伤机制如炎症反应、自噬等有关。近年来研究发现,内质网应激可加重ARDS肺部损伤,其中蛋白质稳态失衡可诱发激活未折叠蛋白反应(unfolded protein response,UPR)。UPR可通过介导跨膜蛋白相关的信号通路来重建内质网的内稳态,而持续过度的内质网应激将促进细胞凋亡和自噬的发生。该文就UPR在ARDS肺损伤相关的信号通路以及炎性效应等方面的研究进展作一综述。 Acute respiratory distress syndrome(ARDS)is a severe respiratory disease in children and the pathogenesis is not fully defined.It is mainly related to various mechanisms of lung injury such as inflammation and autophagy.In recent years,studies have found that,endoplasmic reticulum stress(ERS)can aggravate lung injury in ARDS,in which protein homeostasis imbalance can induce activation of the unfolded protein response(UPR).The UPR reconstructs homeostasis by mediating transmembrane protein-related signaling pathways,while continuous excessive ERS will promote apoptosis and autophagy.This review summarizes the progress of the signaling pathway of UPR related to lung injury and its inflammatory effect in ARDS.
作者 李沛隆(综述) 付红敏(审校) Li Peilong;Fu Hongmin(Department of Pulmonary and Critical Care Medicine,Yunnan Key Laboratory of Children's Major Disease Research,Kunming Children's Hospital,Kunming 650034,China)
出处 《国际儿科学杂志》 2023年第6期393-396,共4页 International Journal of Pediatrics
基金 国家自然科学基金(81960021)。
关键词 内质网应激 未折叠蛋白反应 急性呼吸窘迫综合征 信号通路 Endoplasmic reticulum stress Unfolded protein response Acute respiratory distress syndrome Signal pathway
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