DNA甲基化与类风湿关节炎发生、发展、诊断、治疗和预后关系的研究进展

Research progress on relationship between DNA methylation and occurrence,development,diagnosis,treatment and prognosis of rheumatoid arthritis

类风湿关节炎(RA)是一种常见的慢性自身免疫性疾病。脱氧核糖核酸(DNA)甲基化是一种重要的表观遗传修饰。本文对近年DNA甲基化与RA发生、发展、诊断、治疗和预后关系研究进行了综述,发现DNA甲基化与RA的发生和发展密切相关,有希望作为RA诊断、治疗和预后的新靶点。其中,MAP3K5和LBH等甲基化基因参与RA发病阶段的调控,CYP2E1和DUSP22等甲基化基因调控RA的发展过程,SHROOM1等甲基化基因可用于RA的诊断,Foxp3和patched 1(PTCH1)等基因甲基化水平可用于评价RA的治疗效果。此外,给药前后的整体甲基化水平改变可用于RA的预后,有利于加深RA发病机制、疾病过程在表观遗传学上的认识。

Rheumatoid arthritis(RA)is a chronic autoimmune disease.DNA methylation is one of the important epigenetic modifications.This article reviewed recent research on RA and DNA methylation and summarized the relationship between DNA meth⁃ylation and the occurrence,development,diagnosis,treatment and prognosis of RA.It has been reported that DNA methylation is re⁃lated to the occurrence and development of RA,and it is a promising target for the diagnosis,treatment and prognosis of RA.Among them,the methylation of MAP3K5 and LBH genes are involved in the regulation of the pathogenesis of RA.The methylation of CYP2E1 and DUSP22 genes regulate the development of RA.The methylation of SHROOM1 gene can be used for the diagnosis of RA.The treatment of RA can be evaluated from the methylation levels of Foxp3 and patched 1(PTCH1)genes.In addition,changes in global methylation levels before and after drugs treatment can be used for predicting the prognosis of RA.This research will give us a deepen understanding in the pathogenesis and progression of RA at epigenetics level.