多发性硬化的表观遗传学研究进展

Advances in epigenetics of multiple sclerosis

多发性硬化是一种以中枢神经系统白质脱髓鞘病变为主的自身免疫性疾病。表观遗传学是不影响DNA碱基序列,而基因表达发生变化。越来越多的研究表明,表观遗传学参与多发性硬化的发生和发展。碱基修饰、组蛋白翻译后修饰、微小RNA(miRNA)及长链非编码RNA(LncRNA)等表观遗传学过程影响多发性硬化的免疫调节。本文就相关研究进行综述,以期为多发性硬化的发病机制提供新的认识。

Multiple sclerosis is an autoimmune disease characterized by demyelination of white matter in central nervous system.Epigenetics means that changes to the genome that affect how DNA is packaged and expressed without altering its sequence.More and more studies have shown that epigenetics is involved in the occurrence and development of multiple sclerosis.Epigenetic processes such as base modification,histone post-translational modification,microRNA(miRNA)and long non-coding RNA(LncRNA)affect the immune regulation of multiple sclerosis.In this review,we summarized recent studies on the role of epigenetic changes in the pathogenesis of multiple sclerosis.