NKT细胞与肝纤维化的研究进展

Research progress of NKT cell and hepatic fibrosis

自然杀伤T细胞(NKT)是一类具有NK细胞受体和T细胞受体且显示NK细胞和T细胞两方面性质的T细胞亚群,NKT将先天性免疫应答和获得性免疫应答连接起来,限制性识别CD1d-糖脂类抗原,活化后迅速分泌大量细胞因子从而调节机体的免疫应答。人体的肝脏内富含NKT细胞,因此,NKT细胞在肝脏中的作用引起了人们的广泛兴趣。本文总结了近年来NKT细胞在肝纤维化发生发展中的免疫学研究进展。

Natural killer T cells(NKT)are a class of subgroups of T cells with NK cell receptors and T cell receptors that show both the properties of NK cells and T cells.It linked the innate immune response and acquired immune response,restricted identified CD1d-glycolipid antigens,activation quickly secreted a large number of cytokines to regulate the body's immune response.The human liver is rich in NKT cells,so the role of NKT cells in the liver disease aroused widespread interest.This paper summarizes the progress of immunology in the development of NKT cells in liver fibrosis.