无创正压通气对肺癌重症呼吸衰竭患者的治疗效果

Therapeutic effect of non-invasive positive pressure ventilation in lung cancer patients with severe respiratory failure

目的探讨无创正压通气对肺癌重症呼吸衰竭患者的治疗效果。方法根据治疗方法的不同将80例肺癌重症呼吸衰竭患者分为观察组和对照组,每组40例,对照组患者予以常规对症治疗,观察组患者在对照组的基础上采用无创正压通气。比较两组患者的临床疗效、动脉血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH值]、不良反应发生情况及生活质量[健康调查简表(SF-36)]。结果观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者PaO_(2)、pH值均高于本组治疗前,PaCO_(2)均低于本组治疗前,观察组患者PaO_(2)、p H值均高于对照组,PaCO_(2)低于对照组,差异均有统计学意义(P<0.05)。观察组患者的不良反应总发生率明显低于对照组(P<0.01)。治疗后,两组患者生理职能、生理机能、社会功能、情感职能、精神健康评分均高于本组治疗前,观察组患者上述评分均高于对照组,差异均有统计学意义(P<0.05)。结论无创正压通气对肺癌重症呼吸衰竭患者的治疗效果显著,可有效改善其动脉血气指标,降低不良反应发生率,提高生活质量。

Objective To investigate the therapeutic effect of non-invasive positive pressure ventilation in lung can-cer patients with severe respiratory failure.Method A total of 80 lung cancer patients with severe respiratory failure were divided into control group(n=40,received routine symptomatic treatment)and observation group(n=40,received additional non-invasive positive pressure ventilation on the basis of the control group)according to different treatment methods.The clinical efficacy,arterial blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pres-sure of carbon dioxide(PaCO_(2)),and pH],incidence of adverse reactions and quality of life[the MOS 36-item short form health survey(SF-36)]were compared between the two groups.Result The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the PaO2 and pH of the two groups were higher than those before treatment,and PaCO_(2) of the two groups were lower than those before treatment,with higher PaO_(2) and pH and lower PaCO2 in the observation group than those in the control group(P<0.05).The total incidence of adverse reac-tions in the observation group was significantly lower than that in the control group(P<0.01).After treatment,the scores of role physical,physiological function,social function,emotional function and mental health in the two groups were higher than those before treatment,with higher scores in the observation group than those in the control group(P<0.05).Conclusion Non-invasive positive pressure ventilation is effective in the treatment of lung cancer patients with severe re-spiratory failure,which can effectively improve the arterial blood gas index,reduce the incidence of adverse reactions,and improve the quality of life of patients.