综合干预对肺癌全身麻醉手术患者应激反应指标的影响

Effect of comprehensive intervention on stress response indicators of lung cancer patients undergoing general anesthesia surgery

目的探讨综合干预对肺癌全身麻醉手术患者应激反应指标的影响。方法依据干预方式的不同将145例肺癌全身麻醉手术患者分为综合干预组(n=79)和常规干预组(n=66),常规干预组患者给予常规干预,综合干预组患者给予综合干预。比较两组患者的应激反应指标,包括心率、收缩压、白细胞计数和C反应蛋白水平。结果术前、手术开始、手术结束和返回病房时,两组患者的心率和收缩压均高于本组入院时,综合干预组患者的心率和收缩压均低于常规干预组,差异均有统计学意义(P<0.05);术后第2~5天,两组患者的心率和收缩压均低于本组返回病房时,综合干预组患者的心率和收缩压均低于常规干预组,差异均有统计学意义(P<0.05)。术后第2天,两组患者C反应蛋白水平和白细胞计数均高于本组术前,综合干预组患者C反应蛋白水平和白细胞计数均低于常规干预组,差异均有统计学意义(P<0.05);出院前复查时,综合干预组患者的C反应蛋白水平和白细胞计数均低于本组术前和常规干预组,差异均有统计学意义(P<0.05)。结论综合干预可以有效降低肺癌手术患者心率、收缩压、C反应蛋白及白细胞计数,减轻患者的应激水平。

Objective To investigate the effect of comprehensive intervention on stress response indicators of lung cancer patients undergoing general anesthesia surgery.Method A total of 145 patients with lung cancer undergoing gen-eral anesthesia surgery were divided into comprehensive intervention group(n=79)and routine intervention group(n=66)according to different intervention methods.Patients in the routine intervention group were given routine intervention,and patients in the comprehensive intervention group were given comprehensive intervention.The stress response indica-tors of the two groups were compared,including heart rate,systolic blood pressure,white blood cell count,and C-reactive protein levels.Result Before the operation,at the beginning,the end of the operation and returning to the ward,the heart rate and systolic blood pressure in the two groups were higher than those at admission,and the heart rate and systol-ic blood pressure in the comprehensive intervention group were lower than those in the routine intervention group,and the differences were statistically significant(P<0.05).On the 2-5 days after the operation,the heart rate and systolic blood pressure of the two groups were lower than those when they returned to the ward,and the heart rate and systolic blood pressure in the comprehensive intervention group were lower than those in the routine intervention group,and the differ-ences were statistically significant(P<0.05).On the 2 days after the operation,the levels of C-reactive protein and white blood cell count in the two groups were higher than those before the operation,and the two indicators in the comprehen-sive intervention group were lower than those in the routine intervention group,and the differences were statistically sig-nificant(P<0.05).At the re-examination before discharge,the C-reactive protein level and white blood cell count in the comprehensive intervention group were lower than those before the surgery and routine intervention group,and the differ-ences were statistically significant(P<0.05).Conclusion Comprehensive intervention could effectively reduce heart rate,systolic blood pressure,C-reactive protein,and white blood cell count in patients undergoing lung cancer surgery,and reduce their stress level.