藤龙补中汤联合化疗治疗晚期结直肠癌疗效研究

Observation on the therapeutic effect of Tenglong Buzhong decoction combined with chemotherapy on advanced colorectal cancer

目的:探讨藤龙补中汤剂联合化疗对晚期结直肠癌的治疗效果。方法:选择晚期结直肠癌患者100例,随机分为两组,每组50例,对照组予以奥沙利铂联合卡倍他滨(XELOX)方案治疗;中药组在化疗基础上加藤龙补中汤治疗。比较两组疗程结束后的实体瘤疗效,并比较两组治疗前后中医症候积分、卡氏功能评分(KPS)、简明疲乏量表(BFI)评分、炎症因子、肿瘤标志物、T细胞亚群及不良反应情况。结果:中药组治疗后中医症候积分、KPS评分、BFI评分、炎症因子、肿瘤标志物、T细胞亚群较治疗前明显改善,且中药组改善程度显著优于对照组(均P<0.05);两组治疗期间不良反应分级比较差异有统计学意义(P<0.05);中药组总有效率为44.00%,疾病控制率为80.00%;对照组疗效总有效率为20.00%,疾病控制率为40.00%;中药组总有效率和疾病控制率显著高于对照组(均P<0.05)。结论:藤龙补中汤剂联合化疗治疗晚期结直肠癌可提升疗效,改善癌因性疲乏症状和日常生活能力,降低炎症因子和肿瘤标志物水平,调节免疫功能,减少化疗不良反应。

Objective:To explore the therapeutic effect of Tenglong Buzhong decoction combined with chemotherapy on advanced colorectal cancer.Methods:100 patients with advanced colorectal cancer were randomly selected and divided into two groups,each group with 50 cases.The control group was treated with oxaliplatin+capecitabine(XELOX)regimen,the Chinese medicine group was treated with Tenglong Buzhong decoction on the basis of chemotherapy,and the efficiency of solid tumors after the end of the treatment courses were observed and compared between the two groups.The TCM symptom scores,KPS scores,BFI scores,inflammatory factors,tumor markers,T cell subsets,and toxic side effects were also compared before and after treatment.Results:After treatment,the TCM syndrome scores,KPS scores,BFI scores,inflammatory factors,tumor markers,and T cell subsets in the Chinese medicine group were significantly improved compared with those before treatment,and the improvement degree was significantly better than those in the control group(all P<0.05).There were significant differences in the classification of toxicity and side effects between the two groups by rank sum test(P<0.05).After the treatment,the total effective rate of the Chinese medicine group was 44.00%,and the disease control rate was 80.00%;The total effective rate of the control group was 20.00%,and the disease control rate was 40.00%;The total effective rate and disease control rate of Chinese medicine group were significantly higher than those of control group(all P<0.05).Conclusion:Tenglong Buzhong decoction combined with chemotherapy can improve the overall treatment efficiency of advanced colorectal cancer,improve cancer related fatigue symptoms and daily living ability,reduce the levels of inflammatory factors and tumor markers,regulate immune function,and reduce toxic and side effects of chemotherapy.