2006-2020年中国女性卵巢癌死亡率及寿命损失变化趋势

Change trend of mortality and life loss of ovarian cancer among Chinese women,2006-2020

目的分析2006-2020年中国卵巢癌死亡率及寿命损失变化趋势,为卵巢癌的科学防治提供依据。方法搜集2006-2020年全国死因监测中卵巢癌的死亡数据及人口资料,应用Joinpoint 4.9.1.0软件计算不同地区卵巢癌死亡率的平均年度变化百分比(AAPC)及95%置信区间(95%CI),分析各年龄组卵巢癌的死亡构成及其造成的期望寿命损失。结果2006-2020年,每年中国死因监测女性32304648~137048309人,其中卵巢癌死亡460~3937人,粗死亡率在1.42/10万~2.87/10万之间,呈上升趋势(AAPC=4.46%,95%CI:2.918%~6.032%),标化死亡率在2013-2017年有上升趋势(APC=7.21%,95%CI:0.768%~14.061%),但在2006-2020年总体变化趋势无统计学意义(P>0.05);2020年15~44岁女性卵巢癌死亡构成较2006年显著降低,尤其是农村地区从19.50%降为6.56%,而65岁及以上年龄组死亡构成增加;卵巢癌导致女性期望寿命损失平均值为(0.04±0.01)年,城市和农村地区分别为(0.06±0.01)年和(0.03±0.01)年,差异有统计学意义(P<0.05)。结论2006-2020年中国农村地区卵巢癌死亡率和寿命损失有上升趋势,且存在城乡差异,应加强农村地区卵巢癌早诊早治工作,尤其是要对65岁及以上女性人群进行早期筛查。

Objective To analyze the change trend of mortality and life loss of ovarian cancer in China from 2006 to 2020,and provide the basis for scientific prevention and treatment of ovarian cancer.Methods Ovarian cancer mortality and demographic data from 2006 to 2020 were collected from the National Cause of Death Surveillance.Joinpoint 4.9.1.0 software was used to calculate the average annual percentage change(AAPC)and 95%confidence interval(95%CI)of ovarian cancer mortality in different regions.The death composition in different age groups and the loss of life expectancy caused by ovarian cancer were analyzed.Results From 2006 to 2020,the annual number of women included in the National Cause of Death Surveillance ranged from 32304648 to 137048309,and the annual number of women dying of ovarian cancer ranged from 460 to 3937.The annual crude mortality rate of ovarian cancer ranged from 1.42/105 to 2.87/105,showing an upward trend(AAPC=4.46%,95%CI:2.918%-6.032%).The standardized mortality rate of ovarian cancer increased in 2013-2017(A PC=7.21%,95%CI:0.768%-14.061%),but the overall trend was not statistically significant in 2006-2020(P>0.05).The proportion of ovarian cancer deaths among women aged 15-44 years decreased from 2006 to 2020,especially in rural areas from 19.5%to 6.56%,while it increased in the age group of 65 years and over.The average life expectancy loss among women caused by ovarian cancer was(0.04+0.01)years,which was(0.06±0.01)years in urban areas and(0.03+0.01)years in rural areas,with a statistical difference(P<0.05).Conclusions From 2006 to 2020,the mortality and life loss of ovarian cancer in rural areas of China increased,and there were differences between urban and rural areas.Early diagnosis and treatment of ovarian cancer in rural areas should be strengthened,especially for women aged 65 years and over.