阿维菌素类药物在抗肿瘤方面的研究进展

Research progress of avermectins in anti-tumor

阿维菌素类药物能够影响多种肿瘤的生物学过程,包括肿瘤细胞的增殖和转移、细胞周期阻滞、凋亡和自噬的诱导、肿瘤微环境的调控以及肿瘤干细胞等。阿维菌素类药物在肿瘤治疗中可单独给药,也可联合化疗药物一起使用,逆转肿瘤多药耐药。进一步探索阿维菌素类药物的抗肿瘤机制,可为今后的临床应用提供可靠的实验理论指导。

Avermectins can affect biological processes of multiple tumor,including tumor cell proliferation and metastasis,cell cycle arrest,induction of apoptosis and autophagy,regulation of tumor microenvironment and tumor stem cells.Avermectins can be administered alone or combined with chemotherapeutic drugs to reverse multidrug resistance.To further explore the anti-tumor mechanism of avermectins will provide reliable experimental and theoretical guidance for future clinical application.