氧化应激在胶质瘤放化疗敏感性中的研究进展

Research progress of oxidative stress in the sensitivity of chemoradiotherapy for gliomas

氧化应激后神经胶质瘤细胞中活性氧大量产生并累积,为避免发生细胞功能障碍,胶质瘤细胞可在DNA损伤修复、脂质过氧化和蛋白质修饰等生物过程中做出适应性反应,产生放化疗抵抗。核转录因子红系2相关因子2、溶质载体家族7成员11、谷胱甘肽、微小RNA作为关键调控因子,其表达可调控活性氧水平、改变胶质瘤氧化应激状态、影响放化疗敏感性。深入了解氧化应激与胶质瘤放化疗敏感性的关系,可为胶质瘤精准治疗提供理论依据。

Following oxidative stress,reactive oxygen species are produced and accumulate in glioma cells in large quantities,and to avoid the occurrence of cellular dysfunction,glioma cells can respond adaptively in the biological processes of DNA damage repair,lipid peroxidation and protein modification to produce radiotherapy resistance.The expression of nuclear factor erythroid 2-related factor 2,solute carrier family 7 member 11,glutathione and microRNA,as key regulatory molecules,can regulate reactive oxygen species levels,alter glioma oxidative stress status,and affect radiochemotherapy sensitivity.Further study on the relationship between oxidative stress and sensitivity to radiotherapy and chemotherapy of glioma can provide theoretical basis for precise treatment of glioma.