细胞外基质:对肿瘤发展和治疗的生物学效应

Extracellular matrix:biological effects on tumor development and therapy

免疫疗法具有疗效佳且不良反应少等优点,逐渐成为了癌症治疗的热点。细胞外基质(extracellular matrix,ECM)作为肿瘤微环境的重要组成部分,同时也是造成肿瘤微环境异质性和复杂性的基础,对于肿瘤的发生发展及免疫治疗耐药性的产生具有不可忽视的作用。本文将以肿瘤微环境中的ECM作为探讨中心,重点探讨了ECM中的主要成分,如胶原蛋白、粘连蛋白、生长因子、蛋白水解酶蛋白、多糖复合物以及糖蛋白在肿瘤发展和治疗的重要作用,解析ECM影响肿瘤发展过程的相关机制及可能的有效治疗靶点,以期在肿瘤免疫治疗中提供思路。

With the advantages of good efficacy and few adverse effects,immunotherapy has gradually become a hotspot in cancer treatment.As an important part of the tumor microenvironment,the extracellular matrix(ECM) also contributes to the heterogeneity and complexity of the tumor microenvironment,which has a non negligible role in the development of cancer and the development of resistance to immunotherapy.This review will focus on the ECM in the tumor microenvironment,focusing on the key components of the ECM,such as collagens,adhesins,growth factors,proteolytic enzyme proteins,polysaccharide complexes,and glycoproteins that are important in tumor development and therapy,dissecting the mechanisms by which the ECM influences the process of tumor development and possible effective therapeutic targets with a view to tumor immunotherapyIde as are provided in.