摘要
内源性大麻素系统在特定受体和下游信号通路的参与下影响机体的炎症反应、氧化应激,发挥抗炎或促炎的调节作用。阻塞性睡眠呼吸暂停的特征性病理改变是慢性间歇低氧,导致机体氧化应激水平升高,产生大量氧自由基,引起一系列的炎症反应和血管内皮损伤,进而造成多靶器官的损伤。本综述旨在探讨内源性大麻素受体1在阻塞性睡眠呼吸暂停背景下对机体炎症反应的调节作用。
The endocannabinoid system affects the inflammatory response and oxidative stress with the involvement of specific receptors and downstream signaling pathway,which plays an anti-inflammatory and pro-inflammatory regulatory role.The characteristic pathological changes of obstructive sleep apnea(OSA)include chronic intermittent hypoxia,and subsequent increases in oxidative stress levels,production of a large number of oxygen free radicals,inflammatory reactions and vascular endothelial damage,thus causing multi-target organ damage.This review aims to investigate the regulation of endocannabinoid receptor 1 in the inflammatory response of OSA patients.
作者
石云霞
巩艳平
刘涛
王蓓
Shi Yunxia;Gong Yanping;Liu Tao;Wang Bei(The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030000,China;Department of Sleep Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China;Department of Respiratory and Critical Care Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《国际呼吸杂志》
2023年第7期854-858,共5页
International Journal of Respiration
基金
山西省医学重点科研项目(2022XM29)。
关键词
睡眠呼吸暂停
阻塞性
受体
大麻酚
炎症
低氧
Sleep apnea,obstructive
Receptors,cannabinoid
Inflammation
Hypoxia
