微纳米复合免疫探针设计及其在肿瘤标志物电化学检测中的应用

Design of micro-nanocomposite immunoprobes and its application in electrochemical detection of tumor markers

灵敏检测肿瘤标志物对癌症的早期诊断和预后监测至关重要.电化学免疫传感器因具有灵敏度高、响应快、操作方便、仪器小型化等特点,被广泛用于检测肿瘤标志物.通过微纳米复合免疫探针的载体材料富集信号物质或触发反应(如催化反应或级联反应),提升复合免疫探针的功能,是提高电化学检测性能的有效手段.本文基于微纳米载体材料的特点,对微纳米复合探针的设计及其在肿瘤标志物电化学免疫检测中的应用取得的进展进行了综述,并对有待解决的问题进行了展望.

Sensitive detection of tumor markers is essential for the early diagnosis and prognostic monitoring of cancer.Electrochemical immunosensors are widely used for the detection of tumor markers due to their high sensitivity,rapid response,ease of operation and miniaturization of the instrument.The carrier material of micro-nanocomposite immunoprobe enhances its function by enriching signal substance or triggering reaction(e.g.,catalytic reaction or cascade reaction),which is effective means to improve the performance of electrochemical detection.Based on the characteristics of micro-nanocarrier materials,this article reviews the progress made in the design of micronanocomposite immunoprobes and their application in the electrochemical immunoassay for tumor markers,and provides an outlook on the problems to be solved.