利用CHPS对我院282例药品不良反应的分析

Analysis on 282 Cases of Adverse Drug Reactions in Our Hospital Based on Chinese Hospital Pharmacovigilance System

目的:利用中国医院药物警戒系统(CHPS)对我院药品不良反应(ADR)发生的特点和规律进行分析,以便能更好地开展ADR监测。方法:收集本院2021年1月-12月通过CHPS上报国家药品不良反应监测系统的282例药品不良反应,对涉及ADR患者的性别、年龄、原患疾病、药品种类、药品剂型、累及器官/系统及临床表现、报告类型和转归情况进行统计分析。结果:282例ADR中女性患者发生率高于男性,45~64岁患者所占比例最高,为28.01%(128/457);原患疾病是冠状动脉粥样硬化性心脏病的患者药品不良反应发生率最高;发生不良反应最多的剂型是注射剂;抗肿瘤药引起的不良反应最多;ADR表现以皮肤及附件损害最为常见。结论:药品不良反应的发生与个体因素、药物和临床不合理使用等因素有关,应加强对药品临床使用的监管力度,确保患者用药安全有效。

Objective:To analyze the characteristics and regularity of adverse drug reactions(ADR)in our hospital by using China Hospital Pharmacovigilance System(CHPS),so as to better carry out ADR monitoring.Methods:A total of 282 cases of adverse drug reactions reported to the National Adverse Drug Reaction Monitoring System through CHPS in our hospital from January to December 2021 were collected.The gender,age,primary disease,drug type,drug dosage form,involved organs/systems and clinical manifestations,report types and outcomes of ADR patients were statistically analyzed.Results:Among the 282 cases of ADR,the incidence of female patients was higher than that of male patients,and the proportion of patients aged 45-64 years was the highest(28.01%,128/457).The incidence of adverse drug reactions was the highest in patients with coronary atherosclerotic heart disease.The dosage form with the most adverse reactions was injection;antitumor drugs caused the most adverse reactions.The most common manifestations of ADR were skin and accessories damage.Conclusion:The occurrence of adverse drug reactions is related to individual factors,drugs and unreasonable clinical use.The supervision of clinical use of drugs should be strengthened to ensure the safety and effectiveness of patients’medication.