彩色多普勒超声评估HBV肝硬化失代偿期患者抗病毒治疗效果的研究

Study on the Effect of Antiviral Therapy in Patients with Decompensated HBV Cirrhosis by Color Doppler Ultrasound

目的:探讨彩色多普勒超声评估乙型肝炎病毒(HBV)相关性肝硬化失代偿期抗病毒治疗效果。方法:选择本院2021年9月-2022年9月收治的HBV相关性肝硬化失代偿期患者92例作为研究组,按是否接受抗病毒治疗分为抗病毒组51例与非抗病毒组41例,另选取同时期本院收治的HBV相关性肝硬化代偿期患者90例作为对照组。全部患者均行彩色多普勒超声检查,比较研究组与对照组超声相关指标,并分析抗病毒治疗对超声相关指标的影响,评估治疗效果。结果:研究组肝血流灌注指数(DPI)、搏动指数(PI)、阻力指数(RI)、门静脉充血指数(CI)均高于对照组(P<0.05);抗病毒组治疗后门、脾静脉血流量、血管内径低于治疗前及非抗病毒组,血流速度高于治疗前及非抗病毒组(P<0.05)。结论:彩色多普勒超声评估HBV相关性肝硬化失代偿期抗病毒治疗效果确切,可有效反映肝血流变化情况,临床应用价值较高。

Objective:To investigate the effect of color Doppler ultrasound to evaluate hepatitis B virus(HBV)-related cirrhosis.Methods:A total of 92 patients with HBV-related cirrhosis admitted to our hospital from September 2021 to September 2022 were selected as the study group,51 into antiviral group and 41 antiviral group,and 90 patients with HBV-related cirrhosis admitted to our hospital in the hospital during the same period were selected as the control group.All patients underwent color Doppler ultrasound to compare the ultrasound-related indicators between the study group and the control group,and the effect of antiviral treatment on the ultrasound-related indicators was analyzed to evaluate the treatment effect.Results:The Doppler perfusion inde(DPI),pulsatility index(PI),resistance index(RI)and portal vein congestion index(CI)in the study group were higher than those in the control group(P<0.05).The portal and splenic venous blood flow and vascular diameter after treatment in the antiviral group were lower than those before treatment and in the non-antiviral group,and the blood flow velocity was higher than that before treatment and in the non-antiviral group(P<0.05).Conclusion:The evaluation of HBV-related cirrhosis by color Doppler ultrasound can effectively reflect the changes of liver blood flow,and has a high clinical application value.