间苯三酚辅助盐酸利托君治疗先兆流产的效果

Effect of Phloroglucinol Assisted Ritodrine Hydrochloride in the Treatment of Threatened Abortion

目的:探讨间苯三酚辅助盐酸利托君治疗先兆流产的效果。方法:纳入天津爱维医院于2021年1月-2022年7月收治的87例先兆流产产妇作为研究对象,根据随机数字表法分为传统组(43例)和联合组(44例)。传统组给予间苯三酚治疗,联合组在传统组基础上联合盐酸利托君治疗,比较两组病情缓解情况、血清性激素水平、妊娠结局以及不良反应发生率。结果:联合组阴道出血量少于传统组,出血持续时间及药物起效时间短于传统组,继续妊娠时间长于传统组(P<0.05);联合组绒毛膜促性腺激素(β-hCG)及雌二醇(E2)、孕酮(P)高于传统组(P<0.05);两组胎儿窘迫发生率比较,差异无统计学差异(P>0.05),而联合组早产儿发生率低于传统组(P<0.05);联合组自然分娩发生率高于传统组(P<0.05);联合组不良反应发生率为4.54%,低于传统组的20.92%(P<0.05)。结论:孕20周后先兆流产产妇使用盐酸利托君联合间苯三酚治疗可通过调节血清性激素水平,改善妊娠结局降低剖宫产,减少不良反应的发生,提高治疗效果,对胎儿窘迫无影响。

Objective:To investigate the effect of phloroglucinol assisted ritodrine hydrochloride in the treatment of threatened abortion.Methods:A total of 87 pregnant women with threatened abortion admitted to Tianjin Aiwei Hospital from January 2021 to July 2022 were included as research objects.According to random number table method,they were divided into traditional group(43 cases)and combined group(44 cases).The traditional group was treated with phloroglucinol,and the combined group was treated with ritodrine hydrochloride based on the traditional group.The remission of disease,serum sex hormone levels,pregnancy outcomes and incidence of adverse reactions were compared between the two groups.Results:The amount of vaginal bleeding in the combined group was less than that in the traditional group,the duration of bleeding and drug onset time was shorter than that in the traditional group,and the duration of continued pregnancy was longer than that in the traditional group(P<0.05).Chorionic gonadotropin(β-hCG)and estradiol(E2)progesterone(P)in combination group were higher than those in traditional group(P<0.05).There was no significant difference in the incidence of fetal distress between the two groups(P>0.05),but the incidence of premature infants in the combination group was lower than that in the traditional group(P<0.05).The incidence of natural delivery in combination group was higher than that in traditional group(P<0.05).The incidence of adverse reactions in combination group was 4.54%,which was lower than 20.92%in traditional group(P<0.05).Conclusion:The use of ritodrine hydrochloride combined with phloroglucinol in the treatment of threatened abortion after 20 weeks of pregnancy can improve the pregnancy outcome by regulating the level of serum sex hormones,reduce cesarean section,reduce the occurrence of adverse reactions,improve the therapeutic effect,and have no effect on fetal distress.