加替沙星联合含卷曲霉素化疗方案治疗耐多药肺结核大学生患者的效果研究

Effects of Gatifloxacin Combined with Capreomycin Chemotherapy in the Treatment of College Students with Multidrug-resistant Pulmonary Tuberculosis

目的:探究加替沙星联合含卷曲霉素化疗方案对耐多药肺结核大学生呼吸功能及生活质量的影响。方法:选择2018年3月-2022年3月沈阳理工大学医院和大连市结核病医院发现的耐多药肺结核大学生60例,按照随机数字表法分为观察组(n=30)和对照组(n=30)。对照组予以加替沙星化疗,观察组予以加替沙星联合含卷曲霉素化疗。比较两组治疗效果、痰涂片阴性率、生活质量、呼吸功能、免疫指标和治疗满意度。结果:观察组治疗总有效率为96.67%,高于对照组的73.33%(P<0.05);观察治疗后第1、3、6个月痰涂片阴性率高于对照组(P<0.05);观察组生活质量评分、治疗满意度高于对照组(P<0.05);观察组FVC、FEV1、FEV1/FVC、CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)CD8^(+)大于对照组(P<0.05)。结论:加替沙星联合含卷曲霉素化疗可提高治疗有效率,改善耐多药肺结核大学生的呼吸功能、T淋巴细胞亚群,提高生活质量及患者满意度,值得临床推广使用。

Objective:To explore the effect of gatifloxacin combined with capreomycin-containing chemotherapy regimen on respiratory function and quality of life of college students with multidrug-resistant pulmonary tuberculosis.Methods:A total of 60 college students with multidrug-resistant pulmonary tuberculosis found in the Department of Prevention and Health Care of Shenyang University of Science and Technology Hospital and Dalian Tuberculosis Hospital from March 2018 to March 2022 were selected and divided into an observation group(n=30)and a control group(n=30)according to the random number table method.The control group was given gatifloxacin chemotherapy,while the observation group was given gatifloxacin combined with capreomycin-containing chemotherapy.The treatment effect,negative rate of sputum smear,quality of life,respiratory function,immune indexes and treatment satisfaction were compared between the two groups.Results:The total effective rate of the observation group was 96.67%,which was higher than 73.33% of the control group(P<0.05).The quality of life score and treatment satisfaction in the group were higher than those in the control group(P<0.05);the FVC,FEV1,FEV1/FVC,CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).Conclusion:Gatifloxacin combined with capreomycin-containing chemotherapy can improve the effective rate of treatment,improve the respiratory function,T lymphocyte subsets,quality of life and patient satisfaction of multidrug-resistant pulmonary tuberculosis college students,and is worthy of clinical promotion.