骨质疏松症中HIF-1α诱导的骨细胞铁死亡机制研究进展

Research Progress on the Mechanism of Ferroptosis by HIF-1αInduced in Osteocyte of Osteoporosis

缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)作为缺氧反应的主要调节因子,可通过调控成骨-血管耦合、雌激素分泌、糖酵解等过程来调节机体成骨细胞-破骨细胞代谢之间的平衡,在骨质疏松症的发生发展中发挥重要作用。有研究表明,HIF-1α与铁死亡密切相关。铁死亡作为一种铁依赖性脂质过氧化驱动下诱发细胞死亡的特殊形式,与肿瘤及退行性疾病的发生发展也密切相关。近年来的研究也发现,HIF-1α诱导的骨细胞铁死亡也参与骨质疏松症的发生。基于此,本文综述近年来有关HIF-1α对成骨细胞、破骨细胞、骨髓间充质干细胞及铁死亡分子调控机制,为临床诊疗提供更多的参考。

Hypoxia-inducible factor-1α(HIF-1α),as the main regulator of hypoxia response,may play an important role in osteoporosis development,which can regulate the balance between osteoblast-osteoclast metabolism by regulating osteoblast-vascular coupling,estrogen secretion,glycolysis and other processes.It has been shown that HIF-1αis strongly linked with ferroptosis.As a special form of cell death induced by iron-dependent lipid peroxidation,ferroptosis has been implicated in many diseases,such as carcinogenesis,degenerative disease.Recent studies indicated that HIF-1αinduced to ferroptosis of bone cell,which is involved in osteoporosis genesis and development.Based on this,this review focused on advances in the molecular regulation mechanism of osteoblasts,osteoclasts,bone marrow mesenchymal stem cells and ferroptosis by HIF-1α,in order to provide more references for clinical diagnosis and treatment.