壳聚糖衍生物作为siRNA纳米递送系统材料的研究进展

Research Progress of Chitosan Derivatives as Materials for siRNA Nano-delivery Systems

小干扰RNA(small interfering RNA,siRNA)在治疗疾病方面具有高效性、特异性、瞬时性等优良特性,是目前药物研发关注的焦点。但裸露的siRNA稳定性差、细胞摄取率低,难以发挥其基因沉默作用,因此需要一种优质的递送系统将其递送至靶细胞中,使其发挥作用。大部分纳米递送系统因毒性、载药问题不利于siRNA的转运,而壳聚糖衍生物具有较高的水溶性、安全性、稳定性,已受到广泛关注。本文综述了壳聚糖衍生物应用于siRNA纳米递送系统的研究进展,为正在进行纳米递送系统研究的科研工作者提供参考。

Small interfering RNA(siRNA)has been the focus of attention in the field of drug development for its excellent properties such as efficiency,specificity and transient nature in treating diseases.However,the poor stability and low cellular uptake of naked siRNAs make it difficult for them to exert their gene silencing effects,a high-quality drug delivery system is needed to deliver them to target cells where they can function.Many nano delivery systems are no longer suitable for siRNA transport due to toxicity and drug loading problems,chitosan derivatives are beginning to receive widespread attention because of their high water solubility,safety and stability.This paper reviewed the research progress of chitosan derivatives as siRNA nano-delivery systems and provided a reference for researchers who are interested in the development of nano-delivery systems.